Causes

GEP NE tumors are thought to arise from neuroendocrine cells that grow in an uncontrolled fashion and develop into tumors. What causes these cells to escape the normal brakes that stop them from growing uncontrollably is not entirely understood.

Defective genes often play a role in the development of tumors, and several genes that contribute to the development of GEP NE tumors have been identified. Some of these genes are associated with the inherited disorder, Multiple Endocrine Neoplasia type 1 (MEN1), which increases the risk of developing pancreatic endocrine tumors. Mutations in a gene called MEN1 are involved in causing these tumors to arise.

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